Serotonin, commonly called the ‘feel-good’ neurotransmitter, is primarily associated with mood regulation, happiness, and an overall sense of well-being. But did you know that a significant proportion of your body’s serotonin is produced not in your brain, but in your gut?

Let’s delve into the fascinating interplay between serotonin and digestion, exploring the vital importance of a healthy gut for mental well-being.

The Gut: A Serotonin Factory

Over 90% of the body’s serotonin is produced in the gastrointestinal (GI) tract. This might come as a surprise to many, considering we often relate serotonin with brain function. But the gut, often dubbed the “second brain,” plays a pivotal role in serotonin production. Specialized cells in the gut, called enterochromaffin cells, are the primary site for this neurotransmitter’s synthesis.

The Digestive Role of Serotonin

While in the brain, serotonin modulates mood, emotions, and sleep, in the gut, its functions are somewhat different. Here, serotonin regulates bowel movements, aids in controlling blood flow to different parts of the GI tract, and plays a key role in initiating the nausea response when toxins are present. It’s no wonder then that a disruption in serotonin levels can lead to digestive issues.

Leaky Gut and Serotonin

A ‘leaky gut’, or increased intestinal permeability, can disrupt the balance of serotonin. When the gut lining becomes inflamed or damaged, it can become more porous than it should be, allowing larger particles, like undigested food or toxins, to enter the bloodstream. This can trigger an immune response leading to chronic inflammation, further exacerbating gut health.

Not only does a leaky gut impact nutrient absorption, but it can also impact serotonin production and regulation. This could manifest in symptoms like mood swings, anxiety, or depression, further emphasizing the deep connection between the gut and the brain.

Digestive Health = Mental Well-being

Given the gut’s role in serotonin production, maintaining digestive health is crucial for mental well-being. A balanced diet rich in fiber, staying hydrated, managing stress, and avoiding unnecessary antibiotics can all help in maintaining a healthy gut environment. Fermented foods and probiotics can further assist by promoting the growth of beneficial gut bacteria, which play a role in serotonin production.

Moreover, some studies have found that specific probiotics, often referred to as ‘psychobiotics,’ might have the potential to influence mental health by altering serotonin levels. These findings further bridge the connection between the gut and the brain.


The intricate relationship between serotonin and digestion is a testament to the holistic nature of human health. It underscores the fact that mental well-being isn’t just about the brain but is deeply intertwined with other systems, primarily the gut.

Understanding this connection can pave the way for integrative health approaches, where conditions like depression or anxiety are not just treated from a neurological standpoint, but also by looking at gut health.

So, the next time you’re aiming to boost your mood or mental well-being, remember to consider the health of your gut. After all, a happy gut might just be the key to a happier mind.

Personalized Approach

One size does not fit all when it comes to healthcare. We have unique requirements based on our genetics, lifestyle choices, and individual needs. I always provide a personalized approach to healthcare, allowing us to assess your needs accurately.

If you are ready to take charge of your health and embrace a proactive approach to preventive care, contact me today to schedule your session and start your journey to your health and happiness.

With this practical information, you can have a competitive advantage. You will understand your body and mind better and capitalize on your strengths. This way, I will help you develop a plan to strengthen your weak points in a deliberate and educated manner. No more guessing – the science is here to help you achieve your goals and peak performance.


Dr. Maya Sarkisyan 

If this information picked your curiosity, let me know by emailing me [email protected] and ask for more interesting and relevant information.

Stay tuned and discover “The True Story About Your Health”.

Disclaimer: This is a general information only. Consult with Dr. Maya Sarkisyan before altering or discontinuing any current medications, treatment or care, or starting any diet, exercise or supplementation program, or if you have or suspect you might have a health condition that requires medical attention. 
Share This