EVALUATING HPA AXIS
This is an opportunity for you to evaluate your HPA axis – the hypothalamic-pituitary-adrenal axis also known as “fight-or-flight” . It plays a major role in the way you feel physically and emotionally. If this stress response is balanced, you are feeling well and energetic, but when over-activated it can lead to many issues such as adrenal fatigue, chronic inflammation, gastrointestinal issues, depression, anxiety, insomnia, hormonal imbalance, metabolic dysfunctions, and activation of any underlying autoimmune conditions such as Hashimoto thyroiditis, fibromyalgia, and others.
It’s important to see a connection between the HPA axis and GI tract. Imbalance in the HPA axis can lead to many gastrointestinal chronic conditions, and in which case must be evaluated first. Your GI tract is a home for many beneficial bacteria helping your immune system function properly as well as helping you to digest and absorb nutrients from food you eat. Chronic stress messes up your chemical balance in GI tract and disturbs the ratio between good and opportunistic bacteria causing issues in mucosal lining of your gut.
The adrenal glands located on the top of your kidneys help your body to cope with physical and emotional stress. Adrenals help us adjust to the situation such as a short term stressful event. However, chronic stress results in overworked adrenals and can cause multiple issues throughout the body and central nervous system.
Adrenal glands that are in balance produce adequate amounts of hormones to power us through the day. These hormones impact just about every process in the body, from energy production and immune activity to cellular maintenance and repair. They are key regulators of glucose, insulin and inflammation, and play a major role in bone and muscle building, mood and mental focus, stamina, sex drive and sleep cycles. Adrenal glands that are out of balance can lead to high or low cortisol, and high or low DHEA, with symptoms such as outlined above.
Neurotransmitters are the brain chemicals that facilitate the transmission of signals from one neuron to the next across a synapse. Neurotransmitters work with receptors in the brain to influence and regulate a wide range of processes such as mental performance, emotions, pain response and energy levels. Functioning primarily in the Central Nervous System (CNS), neurotransmitters are the brain’s chemical messengers, facilitating communication among the body’s glands, organs, and muscles. Numerous clinical studies have shown that inadequate neurotransmitter function has a profound influence on overall health and well-being. In fact, imbalances in certain neurotransmitters are associated with most of the prevalent symptoms and conditions seen in practitioners offices today.
This comprehensive test includes:
- 4 point cortisol test to test for 3 stages of adrenal fatigue
- Complete Hormone Panel: Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone (Pg), Testosterone (T), and DHEA.
It will provide crucial information about deficiencies, excesses and daily patterns, which then result in a personalized holistic approach specifically created for your individual situation.
- Neurotransmitters: Serotonin (S), GABA (GA), Dopamine (DP), Epinephrine (E), Norepinephrine (NE), Glutamate (GLU), Glycine (GLY), Histamine (HST), Phenethylamine (PEA)
It will evaluate symptoms such as mood swings, depression, anxiety, fatigue, cravings, brain fog, insomnia, difficulty concentrating, and cognitive function.
Detailed Sample Collection instructions are included in your kit.
This profile includes estrone (E1) and estriol (E3) plus the estrogen quotient. The addition of neurotransmitters to the Comprehensive Plus hormone-only profile provides insight on how HPA axis function may be contributing to symptom manifestation such as mood swings, fatigue, and pain. Because the research on the estrogen quotient and the protective properties of estriol has not been done with men, this profile is currently recommended for women only. This profile should be considered for patients who have:
- Increased risk of developing breast cancer
- History of breast cancer or other hormonally sensitive cancers
- Personal or strong family history of autoimmune disease
- Estrogen dominance related symptoms